IGF-1 Peptides*
IGF-1 LR3 + IGF-1 DES
Researchers seeking these products for laboratory research can explore PepGen-X.com as a supplier specializing in research-use compounds.
IGF-1 peptides are modified forms of insulin-like growth factor-1 investigated for their effects on cell growth, muscle development, nutrient uptake, and metabolic signaling. Two of the most discussed research variants are IGF-1 LR3 and IGF-1 DES, which differ significantly in structure, duration of activity, and research characteristics.
IGF-1 LR3*
Long R3 IGF-1
IGF-1 LR3 is a modified form of IGF-1 designed to have greater biological activity and a substantially longer duration than native IGF-1. Research has focused on its interaction with IGF-1 receptors and downstream pathways involved in cell growth, protein synthesis, glucose metabolism, and tissue development.
Research Benefits
• Strong anabolic signaling — investigated for its ability to activate pathways involved in muscle-cell growth
• Supports muscle-development research — studied for effects on protein synthesis and muscle tissue
• Influences nutrient signaling — IGF-1 plays an important role in cellular nutrient uptake and metabolism
• Extended activity — the LR3 modification provides a substantially longer duration of activity than native IGF-1
• Broad cellular research potential — IGF-1 signaling is involved in muscle, bone, nervous-system, and other tissue research
Identified Risks & Side Effects
• Hypoglycemia — increased IGF-1 activity can affect blood glucose regulation
• Potential effects on abnormal cell growth — IGF signaling is involved in cellular proliferation
• Edema and other systemic effects may occur with elevated IGF-1 activity
• Long-term safety has not been established
• Not FDA-approved
Route: Experimental
Frequency: Varies by research protocol
FDA Status: Research Only
Researcher Note
IGF-1 LR3 is particularly interesting because the LR3 modification was designed to extend biological activity and reduce interaction with IGF-binding proteins. This makes it a useful experimental model for studying prolonged IGF-1 receptor signaling and its effects on cellular growth and metabolism.
IGF-1 DES*
Des(1-3)IGF-1
IGF-1 DES, also known as Des(1-3)IGF-1, is a truncated form of IGF-1 that has reduced affinity for certain IGF-binding proteins. This characteristic has made it an interesting compound for studying IGF-1 receptor activity, cellular growth, and short-duration anabolic signaling.
Research Benefits
• Highly active IGF-1 variant — investigated for its interaction with IGF-1 receptors
• Short-duration research model — provides researchers with a substantially shorter-acting IGF-1 variant
• Supports muscle-cell research — studied for effects on cellular growth and anabolic signaling
• Reduced binding-protein interaction — allows investigation of IGF-1 activity with altered binding characteristics
• Useful for comparative research — provides an interesting contrast to the longer-acting IGF-1 LR3
Identified Risks & Side Effects
• Hypoglycemia — IGF-1 activity can influence glucose regulation
• Potential effects on cellular proliferation require consideration
• Systemic effects are possible despite the compound’s short duration
• Human safety data are limited
• Not FDA-approved
Route: Experimental
Frequency: Varies by research protocol
FDA Status: Research Only
Researcher Note
IGF-1 DES is primarily interesting as a shorter-acting IGF-1 research compound. Its altered structure and reduced binding-protein interaction make it useful for investigating IGF-1 receptor signaling and comparing short-duration activity with longer-acting variants such as IGF-1 LR3.
Disclaimer
FDA Status: Not FDA-approved
Research Classification: Research use only
Compound Type: Modified IGF-1 peptides
All products are intended strictly for research and laboratory use only and are not intended for human or veterinary use.